5 ' flanking variants of resistin are associated with obesity

Summary, in English

Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.

• Författare: JC Engert; MC Vohl; SM Williams; P Lepage; JC Loredo-Osti; J Faith; C Dore; Y Renaud; NP Burtt; A Villeneuve; JN Hirschhorn; D Altshuler; Leif Groop; JP Despres; D Gaudet; TJ Hudson
• Avdelning/ar: Translationell Muskel Forskning
• Publiceringsår: 2002
• Språk: Engelska
• Sidor: 1629-1634
• Publikation/Tidskrift/Serie: Diabetes
• Volym: 51
• Issue: 5
• Länkar: http://dx.doi.org/10.2337/diabetes.51.5.1629
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Diabetes Association Inc.
• Ämne: Endocrinology and Diabetes
• Status: Published
• Forskningsgrupp: Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 1939-327X