Meny

Javascript is not activated in your browser. This website needs javascript activated to work properly.
Du är här

Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

Publiceringsår: 2010
Språk: Engelska
Sidor: 28-43
Publikation/Tidskrift/Serie: Small GTPases
Volym: 1
Nummer: 1
Dokumenttyp: Artikel

Sammanfattning

The development of multicellular organisms is associated with extensive rearrangements of tissues and cell sheets. The driving force for these rearrangements is generated mostly by the actin cytoskeleton. In order to permit the reproducible development of a specific body plan, dynamic reorganization of the actin cytoskeleton must be precisely coordinated in space and time. GTP-exchange factors that activate small GTPases of the Rho family play an important role in this process. Here we review the role of this class of cytoskeletal regulators during important developmental processes such as epithelial morphogenesis, cytokinesis, cell migration, cell polarity, neuronal growth cone extension and phagocytosis in different model systems.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • cytokinesis
  • morphogenesis
  • RhoGEF
  • myosin
  • actin
  • cytoskeleton
  • GTPase

Övriga

Published
Yes
  • ISSN: 2154-1256

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen