Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption
Författare
Summary, in English
Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
2224-2232
Publikation/Tidskrift/Serie
Journal of Bone and Mineral Research
Volym
20
Issue
12
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Cancer and Oncology
Nyckelord
- estrogen receptor
- androgen receptor
- estrogen
- testosterone
- human CD14(+) monocytes
- bone resorption
- osteoclast formation
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1523-4681