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alpha-ketoglutarate (AKG) absorption from pig intestine and plasma pharmacokinetics

Författare:
  • M Dabek
  • Danuta Kruszewska
  • R Filip
  • A Hotowy
  • L Pierzynowski
  • A Wojtasz-Pajak
  • S Szymanczyk
  • J L V Piedra
  • E Werpachowska
  • Stefan Pierzynowski
Publiceringsår: 2005
Språk: Engelska
Sidor: 419-426
Publikation/Tidskrift/Serie: Journal of animal physiology and animal nutrition
Volym: 89
Nummer: 11-12
Dokumenttyp: Artikel
Förlag: Blackwell

Sammanfattning

To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut absorption and conversely FeSO4 and FeSO4/AKG on Fe2+ gut absorption. It is concluded that AKG was significantly better absorbed from the upper small intestine than from the distal sections. Furthermore, low pH, Fe2+ and/or SO42- ions enhanced AKG absorption. The AKG administered to the portal vein was rapidly eliminated from the blood (half-life less than 5 min). The short lifetime for AKG is probably dependent on quick metabolism in the enteorcyetes and liver. However, the prolonged half-life can be related to its low AKG blood concentration. The Fe2+ concentrations in blood increased after FeSO4 and FeSO4/AKG duodenal infusion. The implication of above observations is important for practical application of the AKG in animal and human nutrition as well in medicine.

Disputation

Nyckelord

  • Biology and Life Sciences

Övriga

Published
Yes
  • ISSN: 0931-2439

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