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Interstitial photodynamic therapy - diagnostic measurements and treatment in rat malignant experimental tumours

In English

Författare

Redaktör

  • IJ Bigio
  • GJ Muller
  • GJ Puppels
  • RW Steiner
  • Katarina Svanberg

Summary, in English

A recently developed multiple fibre system for treating malignant tumours with interstitial photodynamic therapy was used in studies on rats with colon adenocarcinoma inoculated into the muscles of the hind legs. The animals were intraperitonially administrated delta -aminolevulinic acid (ALA), which is metabolised to protoporphyrin IX (PpIX) in the tissue. The treatment system consists of a laser light source, a beam-splitting system dividing the light into three or six output fibres and a dosimetry programme calculating the optimal fibre position within the tumour as well as the treatment time needed to obtain a given threshold value of the light dose. One aim of the study was to compare the treatment outcome with the modelled dosimetry predictions. Tumour reduction was examined three days post treatment. A volume decrease was found in 85\% of the treated tumours. The mean volume reduction was 44\%, with one tumour completely disappearing. Histopathological examination three days post treatment showed substantial necrotic parts which, however, to a smaller extent were present also for non-treated tumours. These results indicated that the tumours have been under treated and the light dose has to be increased. Measurements of the build-up and photo-induced bleaching of PpIX using laser-induced fluorescence were also performed during the experiments.

Avdelning/ar

Publiceringsår

2000

Språk

Engelska

Sidor

151-157

Publikation/Tidskrift/Serie

OPTICAL BIOPSY AND TISSUE OPTICS

Volym

4161

Issue

32

Dokumenttyp

Konferensbidrag

Förlag

SPIE

Ämne

  • Atom and Molecular Physics and Optics

Conference name

Conference on Optical Biopsy and Tissue Optics, 2000

Conference date

2000-07-05 - 2000-07-06

Conference place

Amsterdam, Netherlands

Aktiv

Published

ISBN/ISSN/Övrigt

  • ISSN: 0277-786X
  • ISSN: 1996-756X
  • ISBN: 0-8194-3817-0