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Human papillomavirus type-specific risk of cervical cancer in a population with high human immunodeficiency virus prevalence: case-control study

In English

Författare

  • Pontus Naucler
  • Flora Mabota da Costa
  • Joao Leopoldo da Costa
  • Otto Ljungberg
  • Antonio Bugalho
  • Joakim Dillner

Summary, in English

There are limited data on human papillomavirus (HPV) type-specific cervical cancer risk among human immunodeficiency virus (HIV)-positive women. Previous studies have suggested that HPV 16 would be relatively less important as a causative agent among HIV-positive compared with HIV-negative women. This study investigates HPV type-specific cervical cancer risk in a population in which HIV is endemic. At the Central Hospital, Maputo, Mozambique, 221 cervical cancer cases and 203 hospital-based controls were consecutively enrolled. HPV typing from cervical samples, HIV testing and recording of socio-demographic factors were performed. Logistic regression modelling was used to assess HPV type-specific risk and effect modification between HIV and HPV infection. Infection with HPV 16, 18 and 'high-risk non-HPV 16/18 types' (HPV 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59) was associated with cervical cancer in both crude and adjusted analyses. HPV 16 and 18 were the most common types detected in cancer biopsies among both HIV-negative and HIV-positive women. There was no significant evidence of effect modification between any HPV type and HIV infection, and there were no significant differences in the HPV type-specific prevalence when cervical cancers among HIV-positive and HIV-negative women were compared. Within the limitations of the study, the relative importance of different HPV types in cervical carcinogenesis appears not to be modified greatly by HIV infection, suggesting that HPV vaccines might not need to be type-specifically modified to be suitable for populations where HIV is endemic.

Publiceringsår

2011

Språk

Engelska

Sidor

2784-2791

Publikation/Tidskrift/Serie

Journal of General Virology

Volym

92

Issue

12

Dokumenttyp

Artikel i tidskrift

Förlag

Microbiology Society

Ämne

  • Microbiology in the medical area

Status

Published

Forskningsgrupp

  • Pathology, Malmö
  • Clinical Microbiology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1465-2099