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Estrogen upregulates hepatic apolipoprotein M expression via the estrogen receptor

In English

Författare

  • Jiang Wei
  • Yuanping Shi
  • Xiaoying Zhang
  • Yuehua Feng
  • Guanghua Luo
  • Jun Zhang
  • Qinfeng Mu
  • Yanhong Tang
  • Yang Yu
  • Lili Pan
  • Peter Nilsson-Ehle
  • Ning Xu
Visa allt

Summary, in English

Apolipoprotein M (apoM) is present predominantly in high-density lipoprotein (HDL) in human plasma, thus possibly involved in the regulation of HDL metabolism and the process of atherosclerosis. Although estrogen replacement therapy increases serum levels of apoAl and HDL, it does not seem to reduce the cardiovascular risk in postmenopausal women. Therefore, we investigated the effects of estrogen on apoM expression in vitro and in vivo. HepG2 cells were incubated with different concentrations of estrogen with or without the estrogen receptor antagonist, fulvestrant, and apoM expression in the cells was determined. Hepatic apoM expression and serum levels of apoM were also determined in normal and in ovariectomized rats treated with either placebo or estradiol benzoate, using sham operated rats as controls. Estrogen significantly increased mRNA levels of apoM and apoAl in HepG2 cell cultures in a dose- and time-dependent manner; the upregulation of both apolipoproteins was fully abolished by addition of estrogen receptor antagonist In normal rats, estrogen treatment led to an increase in plasma lipid levels including HDL cholesterol, a marked upregulation of apoM mRNA and a significant increase in serum levels of apoM. The same pattern of regulation was found in ovariectomized rats treated with estrogen. Thus, estrogen upregulates apoM expression both in vivo and in vitro by mechanism(s) involving the estrogen receptor. (C) 2011 Elsevier B.V. All rights reserved.

Publiceringsår

2011

Språk

Engelska

Sidor

1146-1151

Publikation/Tidskrift/Serie

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volym

1811

Issue

12

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Medicinal Chemistry
  • Pharmacology and Toxicology

Nyckelord

  • Apolipoprotein M
  • HDL
  • Estrogen
  • Lipid metabolism

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1388-1981