The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK

Summary, in English

The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of whether the DEK-CAN fusion protein might perturb regulation of proliferation in leukemic cells.

• Författare: Malin Ageberg; Urban Gullberg; Anders Lindmark
• Avdelning/ar: Avdelningen för hematologi och transfusionsmedicin
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 268-269
• Publikation/Tidskrift/Serie: Haematologica
• Volym: 91
• Issue: 2
• Länkar: http://www.haematologica.org/journal/2006/910268.pdf
• Dokumenttyp: Artikel i tidskrift
• Förlag: Ferrata Storti Foundation
• Ämne: Hematology
• Nyckelord: leukemia; DEK; proliferation
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1592-8721