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Tuberculosis and HIV Co-Infection

In English

Författare

  • Andrzej Pawlowski
  • Marianne Jansson
  • Markus Skold
  • Martin E. Rottenberg
  • Gunilla Kallenius

Summary, in English

Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the development of one of the two diseases in the presence of the co-infecting organism. We also review possible animal models for studies of the interaction of the two pathogens, and describe gaps in knowledge and needs for future studies to develop preventive measures against the two diseases.

Publiceringsår

2012

Språk

Engelska

Publikation/Tidskrift/Serie

PLoS Pathogens

Volym

8

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Public Library of Science (PLoS)

Ämne

  • Microbiology in the medical area

Status

Published

Forskningsgrupp

  • HIV-1 and HIV-2 host interactions

ISBN/ISSN/Övrigt

  • ISSN: 1553-7366