Infection intensity and infectivity of the tick-borne pathogen Borrelia afzelii.
Författare
Summary, in English
The 'trade-off' hypothesis for virulence evolution assumes that between-host transmission rate is a positive and saturating function of pathogen exploitation and virulence, but there are as yet few tests of this assumption, in particular for vector-borne pathogens. Here, I show that the infectivity (probability of transmission) of the tick-borne bacterium Borrelia afzelii from two of its natural rodent hosts (bank vole and yellow-necked mouse) to its main tick vector increases asymptotically with increasing exploitation (measured as bacterial load in skin biopsies). Hence, this result provides support for one of the basic assumptions of the 'trade-off hypothesis'. Moreover, there was no difference in infectivity between bank voles and yellow-necked mice despite bacterial loads being on average an order of magnitude higher in bank voles, most likely because ticks took larger blood meals from mice. This shows that interspecific variation in host resistance does not necessarily translate into a difference in infectivity.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
1448-1453
Publikation/Tidskrift/Serie
Journal of evolutionary biology
Volym
25
Issue
7
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
John Wiley & Sons Inc.
Ämne
- Biological Sciences
Nyckelord
- Borrelia
- host–parasite interactions
- Lyme borreliosis
- virulence
- zoonotic disease
Status
Published
Projekt
- Borrelia in rodents
Forskningsgrupp
- Molecular Ecology and Evolution Lab
ISBN/ISSN/Övrigt
- ISSN: 1420-9101