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Associations between proteins and heavy metals in urine at low environmental exposures: Evidence of reverse causality

In English

Författare

  • Agnes Chaumont
  • Marc Nickmilder
  • Xavier Dumont
  • Thomas Lundh
  • Staffan Skerfving
  • Alfred Bernard

Summary, in English

Heavy metals can cause renal effects on vulnerable populations but it is uncertain whether these metals still pose health risks at the low exposure levels now prevailing in most industrialized countries. In a cross-sectional study performed on 736 adolescents, we assessed the associations between the concentrations of cadmium and lead in blood and urine and the urinary concentrations of albumin and of low-molecular-weight (LMW) proteins, retinol-binding protein (RBP) and beta(2)-microglobulin. Multiple regression analyses were tested using urinary markers normalized to urinary creatinine or specific gravity. Median metal concentrations were in blood (mu g/L): lead. 15.1, cadmium, 0.18 and in urine (mu g/g creatinine): cadmium, 0.09 and lead, 0.82. Multivariate analyses revealed significant associations in urine between RBP and cadmium as well as between beta(2)-microglobulin and lead whereas no associations were seen with metals in blood. These associations were completely abolished in subjects with increased urinary albumin, which may be explained by the competitive inhibition of LMW protein reabsorption by albumin. Given the evidence that cadmium and lead circulate mainly bound to LMW proteins, these associations observed at low exposure might simply reflect the interindividual variations in the renal uptake of proteins sharing the same affinity for tubular binding sites. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Publiceringsår

2012

Språk

Engelska

Sidor

345-352

Publikation/Tidskrift/Serie

Toxicology Letters

Volym

210

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Pharmacology and Toxicology

Nyckelord

  • Cadmium
  • Lead
  • Heavy metals
  • Proteinuria
  • Albuminuria
  • Retinol-binding
  • protein
  • beta(2)-microglobulin
  • Reverse causality

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1879-3169