Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations

Summary, in English

Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements. Result: 9.4% of the per-protocol population in the trial (n = 96) were in either hidden total (n = 4) or hidden partial (n = 5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified.

• Författare: Margareta Reis; A Aberg-Wistedt; H Agren; AC Akerblad; F Bengtsson
• Avdelning/ar: Avdelningen för klinisk kemi och farmakologi
• Publiceringsår: 2004
• Språk: Engelska
• Sidor: 443-446
• Publikation/Tidskrift/Serie: Journal of Affective Disorders
• Volym: 82
• Issue: 3
• Länkar: http://dx.doi.org/10.1016/j.jad.2004.02.003
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Psychiatry
• Nyckelord: sertraline; SSRI; depression
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1573-2517