Enantioselective synthesis of anti-beta-amido-alpha-hydroxy esters via asymmetric transfer hydrogenation coupled with dynamic kinetic resolution

Summary, in English

The asymmetric transfer hydrogenation of beta-amido-alpha-keto esters providing the corresponding anti-beta-amido-alpha-hydroxy esters via dynamic kinetic resolution is reported. The use of a commercially available, or simply prepared, chiral ruthenium catalyst results in good yields as well as high diastereoselectivities and enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.

• Författare: Marvin Villacrez; Peter Somfai
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2013
• Språk: Engelska
• Sidor: 5266-5268
• Publikation/Tidskrift/Serie: Tetrahedron Letters
• Volym: 54
• Issue: 38
• Länkar: http://dx.doi.org/10.1016/j.tetlet.2013.07.100
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Chemical Sciences
• Nyckelord: Ruthenium; Dynamic kinetic resolution; Asymmetric transfer hydrogenation; Enantioselective; 1; 2-Amino alcohols
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0040-4039