Smooth muscle in tissue remodeling and hyper-reactivity: Airways and arteries.

Summary, in English

Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.

• Författare: Kristina Rydell-Törmänen; Paul-André Risse; Varsha Kanabar; Rushita Bagchi; Michael P Czubryt; Jill R Johnson
• Avdelning/ar: Lungbiologi
• Publiceringsår: 2013
• Språk: Engelska
• Sidor: 13-23
• Publikation/Tidskrift/Serie: Pulmonary Pharmacology & Therapeutics
• Volym: 26
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/22561160?dopt=Abstract; http://dx.doi.org/10.1016/j.pupt.2012.04.003
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Cell and Molecular Biology
• Aktiv: Published
• Forskningsgrupp: Lung Biology
• ISBN/ISSN/Övrigt: ISSN: 1522-9629