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Cadmium-induced bone effect is not mediated via low serum 1,25-dihydroxy vitamin D

In English

Författare

  • Annette Engstrom
  • Staffan Skerfving
  • Jonas Lidfeldt
  • Ann Burgaz
  • Thomas Lundh
  • Göran Samsioe
  • Marie Vahter
  • Agneta Akesson

Summary, in English

Cadmium is a widespread environmental pollutant, which is associated with increased risk of osteoporosis. It has been proposed that cadmium's toxic effect on bone is exerted via impaired activation of vitamin D, secondary to the kidney effects. To test this, we assessed the association of cadmium-induced bone and kidney effects with serum 1,25-dihydroxyvitamin D (1,25(OH)(2)D); measured by enzyme immunoassay. For the assessment, we selected 85 postmenopausal women, based on low (0.14-0.39 mu g/L) or high (0.66-2.1 mu g/L) urinary cadmium, within a cross-sectional population-based women's health survey in Southern Sweden. We also measured 25-hydroxy vitamin D. cadmium in blood, bone mineral density and several markers of bone remodeling and kidney effects. Although there were clear differences in both kidney and bone effect markers between women with low and high cadmium exposure, the 1,25(OH)(2)D concentrations were not significantly different (median, 111 pmol/L (5-95th percentile, 67-170 pmol/L) in low- and 125 pmol/L (66-200 pmol/L) in high-cadmium groups; p = 0.08). Also, there was no association between 1,25(OH)(2)D and markers of bone or kidney effects. It is concluded that the low levels of cadmium exposure present in the studied women, although high enough to be associated with lower bone mineral density and increased bone resorption, were not associated with lower serum concentrations of 1,25(OH)(2)D. Hence, decreased circulating levels of 1,25(OH)(2)D are unlikely to be the proposed link between cadmium-induced effects on kidney and bone. (C) 2008 Elsevier Inc. All rights reserved.

Publiceringsår

2009

Språk

Engelska

Sidor

188-192

Publikation/Tidskrift/Serie

Environmental Research

Volym

109

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Environmental Health and Occupational Health

Nyckelord

  • Bone effects
  • Kidney effects
  • Women
  • Cadmium
  • Vitamin D
  • 25(OH)(2)D
  • 1

Status

Published

Forskningsgrupp

  • Family Medicine and Community Medicine

ISBN/ISSN/Övrigt

  • ISSN: 1096-0953