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Prospective Seroepidemiologic Study of Human Papillomavirus and Other Risk Factors in Cervical Cancer

In English

Författare

  • Lisen Arnheim Dahlstrom
  • Kristin Andersson
  • Tapio Luostarinen
  • Steinar Thoresen
  • Helga Ogmundsdottir
  • Laufey Tryggvadottir
  • Fredrik Wiklund
  • Gry B. Skare
  • Carina Eklund
  • Kia Sjölin
  • Egil Jellum
  • Pentti Koskela
  • Goran Wadell
  • Matti Lehtinen
  • Joakim Dillner
Visa allt

Summary, in English

Background: Several sexually transmitted infections (STI) have been reported to interact with human papillomavirus (HPV) in the etiology of cervical cancer. A large cohort study is required to obtain a both unbiased and stable estimate of their effects. Methods: Four major biobanks in the Nordic Countries containing samples from about 1,000,000 subjects were linked with nation-wide cancer registries. Serum samples from 604 women with invasive cervical cancer (ICC) diagnosed on average 10 years after sampling and 2,980 matched control women were retrieved and analyzed with serology for key STI. Results: Exposure to HPV16 was the strongest risk factor for cervical cancer [ OR = 2.4; 95% confidence interval (CI), 2.0-3.0], particularly for squamous cell carcinoma (OR = 2.9; 95% CI, 2.2-3.7). HPV18 was strongly associated with increased risk for adenocarcinoma (OR = 2.3; 95% CI, 1.3-4.1). Baseline seropositivity for HPV16 did not confer any increased risk for HPV18 DNA-positive cancer and conversely HPV18 seropositivity had no association with HPV16 DNA-positive cancers. HPV6 had no effect on its own (OR = 1.1; 95% CI, 0.9-1.3), but had an antagonistic effect on the risk conferred by HPV16 (P < 0.01). Herpes simplex virus 2 had little or no association (OR = 1.1; 95% CI, 0.8-1.4). Previous exposure to Chlamydia trachomatis, as indicated by serum antibodies, had a strongly increased risk for cervical cancer (OR = 1.9; 95% CI, 1.5-2.3). Conclusions: A large prospective study has assessed the role of different STIs in cervical cancer. Impact: Prospective evidence supports cofactor role of some STI in cervical cancer. Cancer Epidemiol Biomarkers Prev; 20(12); 2541-50. (C) 2011 AACR.

Publiceringsår

2011

Språk

Engelska

Sidor

2541-2550

Publikation/Tidskrift/Serie

Cancer Epidemiology Biomarkers & Prevention

Volym

20

Issue

12

Dokumenttyp

Artikel i tidskrift

Förlag

American Association for Cancer Research

Ämne

  • Cancer and Oncology

Status

Published

Forskningsgrupp

  • Epidemiology
  • Clinical Microbiology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1538-7755