Integrative epigenomic analysis of differential DNA methylation in urothelial carcinoma.

Summary, in English

Urothelial carcinoma of the bladder (UC) is a common malignancy. Although extensive transcriptome analysis has provided insights into the gene expression patterns of this tumor type, the mechanistic underpinnings of differential methylation remain poorly understood. Multi-level genomic data may be used to profile the regulatory potential and landscape of differential methylation in cancer and gain understanding of the processes underlying epigenetic and phenotypic characteristics of tumors.

• Författare: Mattias Aine; Gottfrid Sjödahl; Pontus Eriksson; Srinivas Veerla; David Lindgren; Markus Ringnér; Mattias Höglund
• Avdelning/ar: Genomiska analyser av urinblåscancer; Bröstcancer-genetik; Urological research, Malmö; Avdelningen för translationell cancerforskning; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: Genome Medicine
• Volym: 7
• Issue: 1
• Fulltext: - 4 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25810763?dopt=Abstract; http://dx.doi.org/10.1186/s13073-015-0144-4
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Urothelial Cancer Genomics; Urological research, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1756-994X