Dopamine dysregulation of movement control in l-DOPA-induced dyskinesia.
Författare
Summary, in English
The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by l-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that the motor complications of l-DOPA pharmacotherapy are triggered by transient and large changes in extracellular DA levels. The disruption of presynaptic DA homeostasis sets in motion a cascade of postsynaptic alterations, which prime the brain for a complicated motor response to dopaminomimetic treatment. l-DOPA-induced dyskinesia provides a paradigm to study how the dysregulation of DA release and clearance results in maladaptive neuroplasticity sustaining abnormal patterns of movement.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
236-243
Publikation/Tidskrift/Serie
Trends in Neurosciences
Volym
30
Issue
5
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Neurosciences
Status
Published
Forskningsgrupp
- Basal Ganglia Pathophysiology
ISBN/ISSN/Övrigt
- ISSN: 1878-108X