Meny

Javascript is not activated in your browser. This website needs javascript activated to work properly.
Du är här

Regional transport and metabolism of roivacaine and its CYP3A4 metabolite PPX in human intestine

Författare:
Publiceringsår: 2003
Språk: Engelska
Sidor: 963-972
Publikation/Tidskrift/Serie: Journal of Pharmacy and Pharmacology
Volym: 55
Nummer: 7
Dokumenttyp: Artikel
Förlag: Pharmaceutical Press

Sammanfattning

The major aim of this study was to investigate the CYP3A4 metabolism and polarized transport of ropivacaine and its metabolite 2',6'-pipecoloxylidide (PPX) in tissue specimens from the human small and large intestine. Ropivacaine has been shown to be effective in the treatment of ulcerative colitis in human colon. This study was conducted using a modified Ussing-chamber technique with specimens from jejunum, ileum and colon collected from 11 patients. The local kinetics of ropivacaine and PPX were assessed from their concentration-time profiles in mucosal and serosal compartments. The permeability (P-app) in the absorptive direction for both ropivacaine and PPX increased regionally in the order jejunum

Disputation

Nyckelord

  • Medicine and Health Sciences

Övriga

Published
Yes
  • ISSN: 0022-3573

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen