Aromatic allylation via diazotization: Metal-free C-C bond formation
Författare
Summary, in English
A new method for the synthesis of allyl aromatic compounds not involving any metal-containing reagent or catalyst has been developed. Arylamines substituted with a large number of different substituents were converted via diazotizative deamination with tert-butyl nitrite in allyl bromide and acetonitrile to the corresponding allyl aromatic compounds. The allylation reaction was found to be suitable for larger scale synthesis due to short reaction times, a nonextractive workup, and robustness toward moisture, air, and type of solvent.
Publiceringsår
2002
Språk
Engelska
Sidor
6376-6381
Publikation/Tidskrift/Serie
Journal of Organic Chemistry
Volym
67
Issue
18
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Organic Chemistry
Status
Published
Forskningsgrupp
- Chemical Biology and Therapeutics
ISBN/ISSN/Övrigt
- ISSN: 1520-6904