Synaptic dysfunction in Huntington's disease: a new perspective
Författare
Summary, in English
Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin and is characterized by intraneuronal inclusions and widespread neuronal death at the late stage of the disease. In research, most of the emphasis has been on understanding the cell death and its mechanisms. Until recently, it was believed that the vast majority, if not all, of the symptoms in HD are a direct consequence of neurodegeneration. However, increasing evidence shows that subtle alterations in synaptic function could underlie the early symptoms. It is of particular interest to understand the nature of this neuronal dysfunction. Normal huntingtin interacts with various cytoskeletal and synaptic vesicle proteins that are essential for exocytosis and endocytosis. Altered interactions of mutant huntingtin with its associated partners could contribute to abnormal synaptic transmission in HD. This review describes recent advances in understanding synaptic dysfunction in HD.
Publiceringsår
2005
Språk
Engelska
Sidor
1901-1912
Publikation/Tidskrift/Serie
Cellular and Molecular Life Sciences
Volym
62
Issue
17
Dokumenttyp
Artikel i tidskrift
Förlag
Birkhäuser Verlag
Ämne
- Cell Biology
Nyckelord
- pathophysiology
- neurotransmission
- Huntington's disease
- exocytosis
- synaptic protein
- endocytosis
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1420-9071