Synthesis of (-)-pregaliellalactone, conversion of (-)-pregaliellalactone to (-)-galiellalactone by mycelia of Galiella rufa

Summary, in English

An enantioselective synthesis of (-)-pregaliellalactone (1), a biosynthetic precursor of the potent fungal metabolite ( -)-galiellalactone (3) produced by several ascomycetes, is reported. When fed to a culture of Galiella rufa, 1 was efficiently converted to 3. (C) 2002 Elsevier Science Ltd. All rights reserved.

• Författare: Martin H Johansson; B Kopcke; H Anke; Olov Sterner
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2002
• Språk: Engelska
• Sidor: 2523-2528
• Publikation/Tidskrift/Serie: Tetrahedron
• Volym: 58
• Issue: 13
• Länkar: http://dx.doi.org/10.1016/S0040-4020(02)00134-5
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Organic Chemistry
• Nyckelord: pregaliellalactone; stannylation; Diels-Alder cyclisation; Galiella rufa; galiellalactone
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0040-4020