Synthesis of podoscyphic acid
Författare
Summary, in English
Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.
Avdelning/ar
Publiceringsår
2002
Språk
Engelska
Sidor
891-893
Publikation/Tidskrift/Serie
Tetrahedron Letters
Volym
43
Issue
5
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Organic Chemistry
Nyckelord
- enzymatic hydrolysis
- podoscyphic acid
- synthesis lipase
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0040-4039