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Nanomodified surfaces and neurite outgrowth

In English

Författare

Summary, in English

Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with nanoresolution were found to guide neurite outgrowth extending from the dorsal root and the superior cervical ganglion in tissue culture. Ordered arrays of nanowires acted as particularly potent guides for the neurites. Loose nanowires activated the macrophages. We conclude that relatively simple nanomodifications of surfaces can be utilized to guide neurites. This property could potentially be applied to guide neurite outgrowth on implants in the nervous system intended for recordings of electrical and/or chemical activities.

Publiceringsår

2011

Språk

Engelska

Sidor

253-262

Publikation/Tidskrift/Serie

Progress in Brain Research

Volym

194

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Neurosciences

Nyckelord

  • nanostructured materials
  • nerve regeneration
  • ganglia DRG
  • neurite
  • electrodes
  • implants

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1875-7855