Integrated system for interstitial photodynamic therapy

Summary, in English

To develop PDT beyond treatment of thin superficial tumours, to also be an efficient treatment alternative for deeply located and/or thick tumours, a system based on interstitial illumination using multiple fibres has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumours and tumours in the oral cavity. In interstitial PDT one needs to use multiple fibres for light delivery in order to allow treatments of tumours larger than a few millimetres in diameter. Our system consists of a laser light source, a beam-splitting system dividing the light into three or six output fibres and a custom-made dosimetry programme. The concept is then to use these fibres not only for delivering the treatment light but also to measure parameters of interest for the treatment outcome. The fluence rate of the light emitted by each fibre is measured at the positions of the other fibre tips. From these results the light dose at all positions could be recalculated. Changes in optical properties as well as bleaching and concentration of the photosensitizer during the treatment could be monitored and compensated for in the dosimetry. Tumours have been treated both in experimental studies and in patients with thick superficial Basal Cell Carcinomas. Almost all treated skin lesions responded with complete response.

• Författare: Stefan Andersson-Engels; Niels Bendsöe; Thomas Johansson; Sara Pålsson; Marcelo Soto Thompson; Unne Stenram; Katarina Svanberg; Sune Svanberg
• Avdelning/ar: Atomfysik; Institutionen för kliniska vetenskaper, Lund; Tumörmikromiljö; Bröstcancer-genetik
• Publiceringsår: 2002
• Språk: Engelska
• Sidor: 293-302
• Publikation/Tidskrift/Serie: Advanced Optical Devices, Technologies, and Medical Applications
• Volym: 5123
• Fulltext: - 720 kB; Download statistics
• Dokumenttyp: Konferensbidrag
• Förlag: SPIE
• Ämne: Cancer and Oncology
• Nyckelord: optical fibre; diode laser; interstitial photodynamic therapy; ALA; light dosimetry; Basal Cell Carcinoma
• Conference name: Conference on Advanced Optical Devices, Technologies, and Medical Applications
• Conference date: 2002-08-19 - 2002-08-22
• Conference place: Riga, Latvia
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1996-756X; ISSN: 0277-786X