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Trophic Factor Gene Therapy for Parkinson's Disease

In English

Författare

Summary, in English

Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological remedies targeting the dopaminergic network are relatively effective at ameliorating motor deficits, especially in the early stages of the disease, but none of these therapies are curative and many generate their own problems. Recent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell line-derived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in double-blinded analyses. This work reviews the field of trophic factor gene delivery for PD. (C) 2013 Movement Disorder Society

Publiceringsår

2013

Språk

Engelska

Sidor

96-109

Publikation/Tidskrift/Serie

Movement Disorders

Volym

28

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Neurology

Nyckelord

  • Parkinson's disease
  • GDNF
  • neurturin
  • regeneration
  • neuroprotection

Status

Published

Forskningsgrupp

  • Neurobiology

ISBN/ISSN/Övrigt

  • ISSN: 0885-3185