An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

Summary, in English

Key points Hematopoietic stem cell aging associate with stable transcriptional alterations that persist through transplantation.Somatic cell reprogramming of aged hematopoietic stem and progenitor cells reverses functional defects associated with hematopoietic aging.

• Författare: Martin Wahlestedt; Gudmundur Norddahl; Gerd Sten; Amol Ugale; Mary-Ann Micha Frisk; Ragnar Mattsson; Tomas Deierborg; Mikael Sigvardsson; David Bryder
• Avdelning/ar: Institutionen för experimentell medicinsk vetenskap; Stamcellscentrum (SCC); BMC, Biomedicinskt centrum; Immunology; Neuroinflammation; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2013
• Språk: Engelska
• Sidor: 4257-4264
• Publikation/Tidskrift/Serie: Blood
• Volym: 121
• Issue: 21
• Fulltext: - 10 MB; - 6 MB; - 124 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/23476050?dopt=Abstract; http://dx.doi.org/10.1182/blood-2012-11-469080
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Society of Hematology
• Ämne: Hematology
• Status: Published
• Forskningsgrupp: Immunology; Neuroinflammation
• ISBN/ISSN/Övrigt: ISSN: 1528-0020