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Regulation of human papillomavirus gene expression by splicing and polyadenylation.

In English

Författare

Summary, in English

Human papillomaviruses (HPVs) are small DNA tumour viruses that are present in more than 99% of all cervical cancers. The ability of these viruses to cause disease is partly attributed to the strict coordination of viral gene expression with the differentiation stage of the infected cell. HPV gene expression is regulated temporally at the level of RNA splicing and polyadenylation, and a dysregulated gene expression programme allows some HPV types to establish long-term persistence, which is a risk factor for cancer. In this Review, we summarize the role of splicing and polyadenylation in the regulation of HPV gene expression and discuss the viral and cellular factors that control these processes.

Publiceringsår

2013

Språk

Engelska

Sidor

239-251

Publikation/Tidskrift/Serie

Nature Reviews. Microbiology

Volym

11

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Microbiology in the medical area

Status

Published

Forskningsgrupp

  • Molecular virology

ISBN/ISSN/Övrigt

  • ISSN: 1740-1534