G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.

Summary, in English

G protein-coupled estrogen receptor 1 (GPER1), previously named GPR30, is a membrane receptor reported to mediate nongenomic estrogen responses. We investigated if GPER1 expression correlates with any clinicopathologic variables and distant disease-free survival (DDFS) in patients with breast cancer, if any prognostic impact of the receptor is dependent on estrogen receptor-α (ER-α) status, and if the receptor impacts apoptotic signaling in ER-positive breast cancer cells.

• Författare: Stefan Broselid; Benxu Cheng; Martin Sjöström; Kristina Lövgren; Heather L P Klug-De Santiago; Mattias Belting; Karin Jirström; Per Malmström; Björn Olde; Pär-Ola Bendahl; Linda Werner Hartman; Mårten Fernö; Fredrik Leeb-Lundberg
• Avdelning/ar: Drug Target Discovery; Bröstcancer-genetik; Tumörmikromiljö; Kardiologi; Medicinsk onkologi; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2013
• Språk: Engelska
• Sidor: 1681-1692
• Publikation/Tidskrift/Serie: Clinical Cancer Research
• Volym: 19
• Issue: 7
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/23554355?dopt=Abstract; http://dx.doi.org/10.1158/1078-0432.CCR-12-2376
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Association for Cancer Research
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Drug Target Discovery
• ISBN/ISSN/Övrigt: ISSN: 1078-0432