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Catabolism of pyrimidines in yeast: A tool to understand degradation of anticancer drugs

Författare:
  • Gorm Andersen
  • A. Merico
  • Olof Björnberg
  • Birgit Andersen
  • K. D. Schnackerz
  • D. Dobritzsch
  • Jure Piskur (Professor)
  • C. Compagno
Publiceringsår: 2006
Språk: Engelska
Sidor: 991-996
Publikation/Tidskrift/Serie: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volym: 25
Nummer: 9-11
Dokumenttyp: Artikel
Förlag: TAYLOR & FRANCIS INC

Sammanfattning

The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved in degradation of several chemotherapeutic drugs, such as 5-fluorouracil; it also is important in plants, unicellular eukaryotes, and bacteria for the degradation of pyrimidine-based biocides/antibiotics. During the last decade we have developed a yeast species, Saccharomyces kluyveri, as a model and tool to study the genes and enzymes of the pyrimidine catabolic pathway. In this report, we studied degradation of uracil and its putative degradation products in 38 yeasts and showed that this pathway was present in the ancient yeasts but was lost approximately 100 million years ago in the S. cerevisiae lineage.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • yeast
  • uracil degradation
  • pyrimidines
  • evolution
  • cancer

Övriga

Published
Yes
  • ISSN: 1525-7770

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