The synthesis of bicyclo[2.2.2]octan-2,6-dione revisited

Summary, in English

The cyclisation conditions for the formation of bicyclo[2.2.2]octan-2,6-di one (1) from 3-substituted cyclohexanones 2 and 3 have been re-investigated. Use of a medium consisting of isobutyric anhydride and trifluoroacetic acid resulted in a simplified and reproducible method for large-scale synthesis of this compound.

• Författare: Magnus Widegren; Melanie Dietz; Annika Friberg; Torbjörn Frejd; Bärbel Hahn-Hägerdal; Marie-Francoise Gorwa-Grauslund; Mikael Katz
• Avdelning/ar: Kemiska institutionen; Centrum för analys och syntes; Teknisk mikrobiologi
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 3527-3530
• Publikation/Tidskrift/Serie: Synthesis
• Issue: 20
• Länkar: http://dx.doi.org/10.1055/s-2006-942532
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford Polytechnic, Oxford
• Ämne: Organic Chemistry; Industrial Biotechnology
• Nyckelord: carboxylic acids; diketones; bicyclic compounds; cyclisations; anhydrides
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0039-7881