MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia
Författare
Summary, in English
AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
1287-1288
Publikation/Tidskrift/Serie
Haematologica
Volym
91
Issue
9
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Ferrata Storti Foundation
Ämne
- Hematology
Nyckelord
- GAS7
- MLL
- ALL
- translocation
- fusion
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1592-8721