Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.

Summary, in English

To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.

• Författare: Josef Davidsson; Srinivas Veerla; Bertil Johansson
• Avdelning/ar: Avdelningen för klinisk genetik; Bröstcancer-genetik; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2013
• Språk: Engelska
• Publikation/Tidskrift/Serie: Epigenetics & Chromatin
• Volym: 6
• Issue: 1
• Fulltext: - 1 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/23816241?dopt=Abstract; http://dx.doi.org/10.1186/1756-8935-6-18
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Medical Genetics
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1756-8935