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Deregulation of protein phosphatase expression in acute myeloid leukemia

Författare

Summary, in English

Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.

Avdelning/ar

Publiceringsår

2013

Språk

Engelska

Publikation/Tidskrift/Serie

Medical Oncology

Volym

30

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Humana Press

Ämne

  • Cancer and Oncology

Nyckelord

  • Dual specificity
  • Protein serine/threonine phosphatase
  • phosphatase
  • Protein tyrosine
  • Protein phosphatase
  • Acute myeloid leukemia
  • AML

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1559-131X