A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax

Summary, in English

Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years. Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin ( tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.

• Författare: Nicholas Brodszki; John-Kalle Länsberg; Michael Dictor; Erik Gyllstedt; Sven-Börje Ewers; Marcus Larsson; Erik Eklund
• Avdelning/ar: Pediatrik, Lund; Tumörmikromiljö; Thoraxkirurgi; Bröstcancer-genetik; Matrix Biology
• Publiceringsår: 2011
• Språk: Engelska
• Sidor: 1448-1453
• Publikation/Tidskrift/Serie: Acta Pædiatrica
• Volym: 100
• Issue: 11
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/21605166?dopt=Abstract; http://dx.doi.org/10.1111/j.1651-2227.2011.02361.x
• Dokumenttyp: Artikel i tidskrift
• Förlag: Wiley-Blackwell
• Ämne: Cancer and Oncology
• Nyckelord: Acute respiratory failure; Alpha-interferon therapy; Heparin
• Status: Published
• Forskningsgrupp: Matrix Biology
• ISBN/ISSN/Övrigt: ISSN: 1651-2227