Cyclin e overexpression reduces infiltrative growth in breast cancer - Yet another link between proliferation control and tumor invasion

Summary, in English

Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.

• Författare: Pontus Berglund; Göran Landberg
• Avdelning/ar: Patologi, Malmö
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 606-609
• Publikation/Tidskrift/Serie: Cell Cycle
• Volym: 5
• Issue: 6
• Länkar: http://www.landesbioscience.com/journals/cc/abstract.php?id=2569; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16582601&dopt=Abstract
• Dokumenttyp: Artikel i tidskrift
• Förlag: Landes Bioscience
• Ämne: Cell Biology
• Nyckelord: medullary breast; proliferation; invasion; breast cancer; cyclin E; microarray; cancer
• Status: Published
• Forskningsgrupp: Pathology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1551-4005