The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus

Summary, in English

In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).

• Författare: V Mierau; Veronica de la Parra; Olov Sterner; T Anke
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 53-56
• Publikation/Tidskrift/Serie: Journal of Antibiotics
• Volym: 59
• Issue: 1
• Länkar: http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article
• Dokumenttyp: Artikel i tidskrift
• Förlag: Japan Antibiotics Research Association
• Ämne: Organic Chemistry
• Nyckelord: activities; cytotoxic; Dasyscyphus niveus; niveulone; dasyscyphins; A similar to C
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0021-8820