Innate immunity and genetic determinants of urinary tract infection susceptibility.

Summary, in English

Urinary tract infections (UTIs) are common, dangerous and interesting. Susceptible individuals experience multiple, often clustered episodes, and in a subset of patients, infections progress to acute pyelonephritis (APN), sometimes accompanied by uro-sepsis. Others develop asymptomatic bacteriuria (ABU). Here, we review the molecular basis for these differences, with the intention to distinguish exaggerated host responses that drive disease from attenuated responses that favour protection and to highlight the genetic basis for these extremes, based on knock-out mice and clinical studies.

• Författare: Gabriela Godaly; Ines Ambite; Catharina Svanborg
• Avdelning/ar: Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG; Klinisk mikrobiologi, Malmö
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 88-96
• Publikation/Tidskrift/Serie: Current Opinion in Infectious Diseases
• Volym: 28
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25539411?dopt=Abstract; http://dx.doi.org/10.1097/QCO.0000000000000127
• Dokumenttyp: Artikel i tidskrift
• Förlag: Lippincott Williams & Wilkins
• Ämne: Infectious Medicine
• Status: Published
• Forskningsgrupp: Clinical Microbiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1473-6527