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Convergence of Synapses, Endosomes, and Prions in the Biology of Neurodegenerative Diseases.

In English

Författare

Summary, in English

Age-related misfolding and aggregation of disease-linked proteins in selective brain regions is a characteristic of neurodegenerative diseases. Although neuropathological aggregates that characterize these various diseases are found at sites other than synapses, increasing evidence supports the idea that synapses are where the pathogenesis begins. Understanding these diseases is hampered by our lack of knowledge of what the normal functions of these proteins are and how they are affected by aging. Evidence has supported the idea that neurodegenerative disease-linked proteins have a common propensity for prion protein-like cell-to-cell propagation. However, it is not thought that the prion-like quality of these proteins/peptides that allows their cell-to-cell transmission implies a role for human-to-human spread in common age-related neurodegenerative diseases. It will be important to better understand the molecular and cellular mechanisms governing the role of these aggregating proteins in neural function, especially at synapses, how their propagation occurs and how pathogenesis is promoted by aging.

Publiceringsår

2013

Språk

Engelska

Publikation/Tidskrift/Serie

International Journal of Cell Biology

Volym

2013

Dokumenttyp

Artikel i tidskrift

Förlag

Hindawi Limited

Ämne

  • Neurosciences

Status

Published

Forskningsgrupp

  • Experimental Dementia Research

ISBN/ISSN/Övrigt

  • ISSN: 1687-8876