Intergrated system for interstitial photodynamic therapy

Summary, in English

To develop PDT beyond treatment of thin superficial tumors, to also be an efficient treatment alternative to deeply located and/or thick tumors, a system based on interstitial illumination using multiple fibers has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumors and tumors in the oral cavity. In interstitial PDT one needs to use multiple fibers for light delivery in order to allow treatments of tumors larger than a few millimeters in diameter. Our sytem consists of a laser light source, a beam-splitting system dividing the light into three or six output fibers and a custom-made dosimetry program. The concept is then to use these fibers not only for delivering the treatment light, but also to measure parameters of interest for the treatment outcome. The fluence rate of the light emitted by each fiber is measured at the positions of the other fiber tips. From these results the light dose at all positions could be recalculated. Changes in optical properties as well as bleaching and concentration of the photosensitizer during the treatment could be monitored and compensated for in the dosimetry. Tumors have been treated both in experimental studies and in patients with thick superficial Basal Cell Carcinomas. Almost all treated skin lesions responded with complete response.

• Författare: Stefan Andersson-Engels; Niels Bendsöe; Thomas Johansson; Sara Pålsson; Marcelo Soto Thompson; Unne Stenram; Katarina Svanberg; Sune Svanberg
• Avdelning/ar: Atomfysik; Institutionen för kliniska vetenskaper, Lund; Tumörmikromiljö; Bröstcancer-genetik
• Publiceringsår: 2003
• Språk: Engelska
• Sidor: 293-302
• Publikation/Tidskrift/Serie: Proceedings of SPIE
• Volym: 5123
• Länkar: http://dx.doi.org/10.1117/12.517035
• Dokumenttyp: Artikel i tidskrift
• Förlag: SPIE
• Ämne: Clinical Medicine
• Status: Published