Lentiviral Vectors for Use in the Central Nervous System.
Författare
Summary, in English
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vectors, and the application of siRNA's using lentiviral vectors. We also describe some of the features that make lentiviral vectors a likely candidate for human gene therapy in the brain.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
484-493
Publikation/Tidskrift/Serie
Molecular Therapy
Volym
13
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Medical Genetics
Nyckelord
- neurological disorders
- brain
- lentivirus
- gene therapy
- siRNA
- Tet system
Status
Published
Forskningsgrupp
- CNS Gene Therapy
ISBN/ISSN/Övrigt
- ISSN: 1525-0024