Orthotopic Wilms tumor xenografts derived from cell lines reflect limited aspects of tumor morphology and clinical characteristics.

Summary, in English

Wilms tumor (WT) is a pediatric tumor of the kidney, the treatment of which includes heavy chemotherapy. Affected children would likely benefit from more targeted therapies with limited side effects. Establishment of relevant orthotopic WT xenografts is important to better understand mechanisms of WT growth and for preclinical drug testing.

• Författare: Linda Holmquist Mengelbier; Daniel Bexell; Daniel Sehic; Cristina Ciornei; David Gisselsson Nord
• Avdelning/ar: Avdelningen för klinisk genetik; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Avdelningen för translationell cancerforskning; Njurmedicin
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 1949-1954
• Publikation/Tidskrift/Serie: Pediatric Blood & Cancer
• Volym: 61
• Issue: 11
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25044705?dopt=Abstract; http://dx.doi.org/10.1002/pbc.25131
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Pediatrics
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1545-5017