Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Summary, in English

Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.

• Författare: Stine A Danielsen; Guro E Lind; Matthias Kolberg; Maren Høland; Bodil Bjerkehagen; Kirsten Sundby Hall; Eva van den Berg; Fredrik Mertens; Sigbjørn Smeland; Piero Picci; Ragnhild A Lothe
• Avdelning/ar: Avdelningen för klinisk genetik; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 63-69
• Publikation/Tidskrift/Serie: Neuro-Oncology
• Volym: 17
• Issue: 1
• Fulltext: - 212 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25038505?dopt=Abstract; http://dx.doi.org/10.1093/neuonc/nou140
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford University Press
• Ämne: Medical Genetics
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1523-5866