The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer.

Summary, in English

Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 and PDGFRα, their gene copy number, and prognosis in TNBC compared to non-TNBC.

• Författare: Sara Jansson; Pär-Ola Bendahl; Dorthe Grabau; Anna-Karin Falck; Mårten Fernö; Kristina Aaltonen; Lisa Rydén
• Avdelning/ar: Bröstcancer-genetik; The Liquid Biopsy och Tumörprogression i Bröstcancer; Kirurgi, Lund; Tumörmikromiljö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2014
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 9
• Issue: 7
• Fulltext: - 1 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25025175?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0102176
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: The Liquid Biopsy and Tumor Progression in Breast Cancer
• ISBN/ISSN/Övrigt: ISSN: 1932-6203