Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Summary, in English

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

• Författare: Gustav Smith; Kevin Luk; Christina-Alexandra Schulz; James C Engert; Ron Do; George Hindy; Gull Rukh; Line Dufresne; Peter Almgren; David S Owens; Tamara B Harris; Gina M Peloso; Kathleen F Kerr; Quenna Wong; Albert V Smith; Matthew J Budoff; Jerome I Rotter; L Adrienne Cupples; Stephen Rich; Sekar Kathiresan; Marju Orho-Melander; Vilmundur Gudnason; Christopher J O'Donnell; Wendy S Post; George Thanassoulis
• Avdelning/ar: Kardiologi; Diabetes - kardiovaskulär sjukdom; Translationell Muskel Forskning; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 1764-1771
• Publikation/Tidskrift/Serie: JAMA: The Journal of the American Medical Association
• Volym: 312
• Issue: 17
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25344734?dopt=Abstract; http://dx.doi.org/10.1001/jama.2014.13959
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Medical Association
• Ämne: Endocrinology and Diabetes
• Status: Published
• Forskningsgrupp: Diabetes - Cardiovascular Disease; Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 1538-3598