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Mammography and Osteoporosis Screening-Clinical Risk Factors and Their Association With Digital X-Ray Radiogrammetry Bone Mineral Density.

In English

Författare

  • Michael L Wilczek
  • Christel Nielsen
  • Johan Kälvesten
  • Jakob Algulin
  • Torkel B Brismar

Summary, in English

The aim of this study was to study the association between digital X-ray radiogrammetry (DXR) T-score and clinical risk factors for osteoporosis. Women were recruited 2 d per wk at a single mammography screening center between year 2010 and 2012. Included women answered a questionnaire about risk factors for osteoporosis, and a radiograph of the nondominant hand was obtained for DXR analysis. Univariate associations between DXR T-score and risk factors were examined. A generalized linear regression model was fitted to independent variables with univariate associations at p < 0.05. The multivariable model was reduced through manual backward elimination, with p > 0.1 as the exclusion criterion. Seventy-six percent of the women chose to participate in the study (n = 8810). The difference in number of daily mammograms performed on study vs nonstudy days was not significant. All univariate associations between DXR T-score and potential risk factors were highly significant. The multivariable model included height, weight, age, right-handedness, menopause before age 45, alcohol consumption, cortisone treatment, rheumatic disease, and age × smoking status. The coefficient of determination of the model was 0.37. The association between risk factors for osteoporosis and DXR T-score is similar to previously reported associations with dual-energy X-ray absorptiometry.

Publiceringsår

2015

Språk

Engelska

Sidor

22-29

Publikation/Tidskrift/Serie

Journal of Clinical Densitometry

Volym

18

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Environmental Health and Occupational Health

Status

Published

Forskningsgrupp

  • Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 1094-6950