A major population of mucosal memory CD4(+) T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.

Summary, in English

Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4(+) T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and display innate lymphocyte functionality. The cytokines IL-15 or the DR3 ligand tumor necrosis factor (TNF)-like cytokine 1A (TL1a) induced memory IL-18Rα(+)DR3(+)CD4(+) T cells to produce interferon-γ, TNF-α, IL-6, IL-5, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-22 in the presence of IL-12/IL-18. TL1a synergized with IL-15 to enhance this response, while suppressing IL-15-induced IL-10 production. TL1a- and IL-15-mediated cytokine induction required the presence of IL-18, whereas induction of IL-5, IL-13, GM-CSF, and IL-22 was IL-12 independent. IL-18Rα(+)DR3(+)CD4(+) T cells with similar functionality were present in human skin, nasal polyps, and, in particular, the intestine, where in chronic inflammation they localized with IL-18-producing cells in lymphoid aggregates. Collectively, these results suggest that human memory IL-18Rα(+)DR3(+) CD4(+) T cells may contribute to antigen-independent innate responses at barrier surfaces.Mucosal Immunology advance online publication, 1 October 2014; doi:10.1038/mi.2014.87.

• Författare: Petra Holmkvist; K Roepstorff; Heli Uronen-Hansson; Caroline Sandén; Sigurdur Gudjonsson; Oliver Hultman Patschan; Olof Grip; Jan Marsal; Artur Schmidtchen; L Hornum; Jonas Erjefält; K Håkansson; William Agace
• Avdelning/ar: Slemhinnans immunologi; Leukocyte Migration; Luftvägsinflammation; Urologi; Urological research, Malmö; Internmedicin - epidemiologi; Medicin/akutsjukvård, Lund; Dermatologi och venereologi, Lund
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 545-558
• Publikation/Tidskrift/Serie: Mucosal Immunology
• Volym: 8
• Issue: 3
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25269704?dopt=Abstract; http://dx.doi.org/10.1038/mi.2014.87
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Immunology in the medical area
• Status: Published
• Forskningsgrupp: Mucosal Immunology; Leukocyte Migration; Airway Inflammation and Immunology; Urology; Urological research, Malmö; Internal Medicine - Epidemiology
• ISBN/ISSN/Övrigt: ISSN: 1933-0219