TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.

Summary, in English

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain.

• Författare: Liana Fasching; Adamandia Kapopoulou; Rohit Sachdeva; Rebecca Petri; Marie Jönsson; Christian Männe; Priscilla Turelli; Patric Jern; Florence Cammas; Didier Trono; Johan Jakobsson
• Avdelning/ar: Molekylär neurogenetik; Brain Repair and Imaging in Neural Systems (BRAINS); StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 20-28
• Publikation/Tidskrift/Serie: Cell Reports
• Volym: 10
• Issue: 1
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25543143?dopt=Abstract; http://dx.doi.org/10.1016/j.celrep.2014.12.004
• Dokumenttyp: Artikel i tidskrift
• Förlag: Cell Press
• Ämne: Cell Biology
• Status: Published
• Forskningsgrupp: Molecular Neurogenetics; Brain Repair and Imaging in Neural Systems (BRAINS)
• ISBN/ISSN/Övrigt: ISSN: 2211-1247