Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression

In English

Författare

  • Yasuhiro Yoshimatsu
  • Yulia G. Lee
  • Yuichi Akatsu
  • Luna Taguchi
  • Hiroshi I. Suzuki
  • Sara I. Cunha
  • Kazuichi Maruyama
  • Yuka Suzuki
  • Tomoko Yamazaki
  • Akihiro Katsura
  • S. Paul Oh
  • Teresa A. Zimmers
  • Se-Jin Lee
  • Kristian Pietras
  • Gou Young Koh
  • Kohei Miyazono
  • Tetsuro Watabe
Visa allt

Summary, in English

Lymphatic vessels (LVs) play critical roles in the maintenance of fluid homeostasis and in pathological conditions, including cancer metastasis. Although mutations in ALK1, a member of the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) receptor family, have been linked to hereditary hemorrhagic telangiectasia, a human vascular disease, the roles of activin receptor-like kinase 1(ALK-1) signals in LV formation largely remain to be elucidated. We show that ALK-1 signals inhibit LV formation, and LVs were enlarged in multiple organs in Alk1-depleted mice. These inhibitory effects of ALK-1 signaling were mediated by BMP-9, which decreased the number of cultured lymphatic endothelial cells. Bmp9-deficient mouse embryos consistently exhibited enlarged dermal LVs. BMP-9 also inhibited LV formation during inflammation and tumorigenesis. BMP-9 downregulated the expression of the transcription factor prospero-related homeobox 1, which is necessary to maintain lymphatic endothelial cell identity. Furthermore, silencing prospero-related homeobox 1 expression inhibited lymphatic endothelial cell proliferation. Our findings reveal a unique molecular basis for the physiological and pathological roles of BMP-9/ALK-1 signals in LV formation.

Avdelning/ar

Publiceringsår

2013

Språk

Engelska

Sidor

18940-18945

Publikation/Tidskrift/Serie

Proceedings of the National Academy of Sciences

Volym

110

Issue

47

Dokumenttyp

Artikel i tidskrift

Förlag

National Academy of Sciences

Ämne

  • Cancer and Oncology

Nyckelord

  • lymphangiogenesis
  • angiogenesis
  • blood vascular endothelial cells

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1091-6490