Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.
Författare
Summary, in English
Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in this gene, which we call slalom, display defects in Wg and Hh signaling, which are likely due to the lack of sulfation of glycos aminoglycans by the sulfotransferase sulfateless. Analysis of mosaic mutant ovaries shows that sll function is also essential for dorsal–ventral axis determination, suggesting that sll transports the sulfate donor required for sulfotransferase activity of the dorsal–ventral determinant pipe.
Avdelning/ar
Publiceringsår
2003
Språk
Engelska
Sidor
3635-3644
Publikation/Tidskrift/Serie
EMBO Journal
Volym
22
Issue
14
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Ämne
- Biochemistry and Molecular Biology
Nyckelord
- sulfation
- Pipe
- glycosaminoglycan
- Hedgehog
- Wingless
Status
Published
Forskningsgrupp
- Invertebrate Developmental Biology, Udo Haecker's group
ISBN/ISSN/Övrigt
- ISSN: 1460-2075